Clinical Use Can be used as a confirmatory test for the diagnosis of chronic kidney disease in patients with a decreased GFR as estimated from creatinine. Data suggests that 3. A strategy of measuring cystatin C when the creatinine-based estimate is in this range and then reestimating GFR with the use of both these markers could correctly reclassify a substantial proportion of such patients as not having chronic kidney disease and not being at high risk. Can also be used to screen for CKD among persons who have a creatinine-based GFR estimate of 60 to 74 ml per minute per 1.
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Clinical Use Can be used as a confirmatory test for the diagnosis of chronic kidney disease in patients with a decreased GFR as estimated from creatinine. Data suggests that 3. A strategy of measuring cystatin C when the creatinine-based estimate is in this range and then reestimating GFR with the use of both these markers could correctly reclassify a substantial proportion of such patients as not having chronic kidney disease and not being at high risk.
Can also be used to screen for CKD among persons who have a creatinine-based GFR estimate of 60 to 74 ml per minute per 1. Clin Chem Lab Med. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. Detection of chronic kidney disease with creatinine, cystatin C, and urine albumin-to-creatinine ratio and association with progression to end-stage renal disease and mortality.
JAMA ; Cystatin C identifies chronic kidney disease patients at higher risk for complications. J Am Soc Nephrol. Advances in glomerular filtration rate-estimating equations. Curr Opin Nephrol Hypertens. About NKF.
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See also: Renal function Glomerular filtration rate GFR , a marker of kidney health, is most accurately measured by injecting compounds such as inulin , radioisotopes such as 51chromium- EDTA , I-iothalamate, 99mTc- DTPA or radiocontrast agents such as iohexol , but these techniques are complicated, costly, time-consuming and have potential side-effects. It is inaccurate at detecting mild renal impairment, and levels can vary with muscle mass but not with protein intake. Urea levels might change with protein intake. Cystatin C has a low molecular weight approximately If kidney function and glomerular filtration rate decline, the blood levels of cystatin C rise. Cross-sectional studies based on a single point in time suggest that serum levels of cystatin C are a more precise test of kidney function as represented by the glomerular filtration rate , GFR than serum creatinine levels.
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